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Worked great for GERD. After a while of being on it, it doesn't seem to work that well. I am on 40 mg's/day and now have a stomach ulcer?

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I took this drug at bedtime for GERD. Sick to my stomach all night long. Stopped taking it for one night and wasn't sick at all.

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Furthermore, no difference existed regarding the PPI used (predominantly omeprazole and esomeprazole) and the presence of no or 1 to 2 CYP2C19 loss-of-function alleles.

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Pantoprazole sodium for injection may be administered intravenously through a dedicated line or through a Y-site.

Results of numerous clinical trials indicate that oral pantoprazole is safe and well tolerated for short-term treatment of GERD and for longer term maintenance therapy in patients with healed erosive esophagitis.

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Thus, monitoring of serum gastrin levels and fundic enterochromaffin-like cells is of no clinical relevance even during long-term therapy with PPIs ().

Oral pantoprazole is an effective treatment option for the initial treatment of nonerosive GERD or erosive esophagitis.

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Before taking pantoprazole, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as lansoprazole, omeprazole); or if you have any other allergies.

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The discontinuation of PPIs may result in rebound symptoms requiring further and even continuous PPI use for suppression of symptoms.

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As there is a significant proportion of patients on PPIs that report insufficient control of symptoms, new approaches based on increasing doses and adding additional medications, such as H2RAs, reflect the need for targeting other components of the pathophysiology of acid-related diseases.

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In the present study, we compared with efficacy of omeprazole, pantoprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in the first 7 d of treatment for reflux esophagitis.

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Eating rice, fruits and vegetables, soy products can reduce acidity and keep your stomache more alkaline.

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In long-term international studies involving over 800 patients, a 2- to 3-fold mean increase from the pretreatment fasting serum gastrin level was observed in the initial months of treatment with Pantoprazole at doses of 40 mg per day during GERD maintenance studies and 40 mg or higher per day in patients with refractory GERD.

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For those patients who have not healed after 8 weeks of treatment, an additional 8-week course of PROTONIX may be considered (see INDICATIONS AND USAGE).

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The data available indicate that pantoprazole 20 mg has similar efficacy to omeprazole 20 mg for maintaining endoscopic and symptomatic remission in patients with healed erosive esophagitis ().

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AIM: To perform a systematic review on the efficacy of pantoprazole based therapies in Helicobacter pylori eradication, and to conduct a meta-analysis comparing the efficacy of pantoprazole and other proton pump inhibitors (PPIs) when co-prescribed with antibiotics.

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We characterized the PK profile of pantoprazole delayed-release tablet 20 mg and 40 mg in children aged 6 through 11 years with endoscopically proven GERD (study 1) and in adolescents aged 12 through 16 years with a clinical diagnosis of suspected GERD (study 2).

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In contrast to the obsolete assessment of heartburn as a single outcome criterion, a recently validated symptom assessment scale (ReQuest) () reliably covers a broad range of GERD-related symptoms on a daily basis by its dimension-orientated structure.

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Although investigators agree that GERD is associated with dysmotility and results from an imbalance between normal defensive factors such as esophageal clearance, lower esophageal sphincter tone, and aggressive factors such as acid and pepsin, it has become increasingly clear that the key to controlling symptoms and to healing esophagitis is decreasing the duration of exposure to the acidic refluxate ().

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